Bioinformatic and Molecular Docking Study of Zerumbone and Its Derivates against Colorectal Cancer

The prevalence of colorectal cancer (CRC) is ranked third among all types in both men and women, highlighting the urgency for drug exploration. Zerumbone its derivatives have gained attention their ability to inhibit angiogenesis, invasion, metastasis been tested efficacy against various cells. This study aimed investigate potential targets mechanism action zerumbone colon invasion migration. Bioinformatic analysis was conducted using STITCH STRING identify target genes, molecular docking used search anticancer candidates from 20 derivatives. results revealed that six proteins were targeted by derivatives, including XIAPBIR3 (1TFT), AKT1 (3O96), JAK2 (6VGL), HASP90AA (2XJX), MDM2 (4MDN), XIAPBIR2 (4KJU). Compound 4 found a lower binding energy than as well AZD5363 (pan-Akt inhibitor) when interacting with protein AKT1. makes it most promising candidate treating cancer. Further development, such addition an amine functional group, expected improve potency this molecule through formation hydrogen bonds other interactions bond energy.Keywords: Bioinformatic, docking,